Correction: Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers
نویسندگان
چکیده
Dogs, with their breed-determined limited genetic background, are great models of human disease including cancer. Canine B-cell lymphoma and hemangiosarcoma are both malignancies of the hematologic system that are clinically and histologically similar to human B-cell non-Hodgkin lymphoma and angiosarcoma, respectively. Golden retrievers in the US show significantly elevated lifetime risk for both B-cell lymphoma (6%) and hemangiosarcoma (20%). We conducted genome-wide association studies for hemangiosarcoma and B-cell lymphoma, identifying two shared predisposing loci. The two associated loci are located on chromosome 5, and together contribute ~20% of the risk of developing these cancers. Genome-wide p-values for the top SNP of each locus are 4.6×10 and 2.7×10, respectively. Whole genome resequencing of nine cases and controls followed by genotyping and detailed analysis identified three shared and one B-cell lymphoma specific risk haplotypes within the two loci, but no coding changes were associated with the risk haplotypes. Gene expression analysis of B-cell lymphoma tumors revealed that carrying the risk PLOS Genetics | DOI:10.1371/journal.pgen.1004922 February 2, 2015 1 / 24 a11111
منابع مشابه
Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers
Dogs, with their breed-determined limited genetic background, are great models of human disease including cancer. Canine B-cell lymphoma and hemangiosarcoma are both malignancies of the hematologic system that are clinically and histologically similar to human B-cell non-Hodgkin lymphoma and angiosarcoma, respectively. Golden retrievers in the US show significantly elevated lifetime risk for bo...
متن کاملCorrection: Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers.
in order to correct headings for Table 1 which were incorrect. The headings for Table 1 are now correct in the republished manuscript. Please download this article again to view the correct version. The originally published, uncorrected article and the republished, corrected article are provided here for reference. an open access article distributed under the terms of the Creative Commons Attri...
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